| Primary Identifier | MGI:2443679 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 217692 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway and regulation of axonogenesis. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1). PHENOTYPE: Male mice homozygous for a knock-out allele show abnormal G-protein-coupled receptor (GPCR) agonist stimulation and multiple behavioral anomalies related to dysregulated GPCR signaling, including hyperactivity, enhanced anxiety, learning impairment, social interaction deficits, and increased susceptibility to pharmacologically induced seizures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
