| Primary Identifier | MGI:88278 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 12401 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables molecular carrier activity and steroid binding activity. Acts upstream of or within glucocorticoid metabolic process. Is active in extracellular region. Is expressed in liver; pancreas; and pancreas branching epithelium tip. Used to study corticosteroid-binding globulin deficiency. Human ortholog(s) of this gene implicated in corticosteroid-binding globulin deficiency. Orthologous to human SERPINA6 (serpin family A member 6). PHENOTYPE: Null homozygotes exhibit reduced total plasma corticosterone, increased susceptibility to bacterial infection, attenuation of the stress-induced surge in free corticosterone, and enhanced behavioral response to intense or uncontrollable stress. They exhibit no locomotor sensitization to cocaine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
