| Primary Identifier | MGI:88278 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 12401 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables steroid binding activity. Acts upstream of or within glucocorticoid metabolic process. Located in extracellular space. Is expressed in liver; pancreas; and pancreas tip epithelium. Used to study corticosteroid-binding globulin deficiency. Human ortholog(s) of this gene implicated in corticosteroid-binding globulin deficiency. Orthologous to human SERPINA6 (serpin family A member 6). PHENOTYPE: Null homozygotes exhibit reduced total plasma corticosterone, increased susceptibility to bacterial infection, attenuation of the stress-induced surge in free corticosterone, and enhanced behavioral response to intense or uncontrollable stress. They exhibit no locomotor sensitization to cocaine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
