| Primary Identifier | MGI:102848 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 16625 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Predicted to be active in extracellular space. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). PHENOTYPE: Under high-fat diet feeding conditions, male mice homozygous for a knock-out allele exhibit increased susceptibility to diet-induced obesity, with lower metabolic rates, more severe glucose intolerance and insulin resistance, and increased white adipose tissue inflammation and apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
