| Primary Identifier | MGI:1261847 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 22367 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine kinase activity. Involved in regulation of neuron migration. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). PHENOTYPE: Males homozygous for a hypomorphic gene trap show progressive loss of proliferating spermatogonia, lack of meiotic cells and mature sperm and early onset sterility, whereas females show complete sterility due to defects in meiotic progression during oogenesis and failure of oocyte fertilization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
