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ncRNA Gene : Meg3 maternally expressed 3
Primary Identifier  MGI:1202886 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  17263
Mgi Type  lncRNA gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in chromatin organization. Acts upstream of or within several processes, including determination of adult lifespan; epigenetic programming of gene expression; and lung alveolus development. Is active in nucleus. Is expressed in several structures, including early conceptus; forebrain; genitourinary system; paraxial mesenchyme; and retina. Orthologous to human MEG3 (maternally expressed 3).
PHENOTYPE: Mice heterozygous for disruptions in this gene show lethality and growth retardation that are dependent on the parental origin of the allele and the extent of the deletion of the associated differentially methylated region. [provided by MGI curators]
  • synonyms:
  • R75394,
  • expressed sequence R75394,
  • expressed sequence AW108224,
  • GTL2, imprinted maternally expressed untranslated mRNA,
  • 2900016C05Rik,
  • MGI:2145004,
  • expressed sequence R74756,
  • MGI:1914551,
  • MGI:106343,
  • AW108224,
  • MGD-MRK-32136,
  • AI425946,
  • RIKEN cDNA 3110050O07 gene,
  • MGI:2145132,
  • MGD-MRK-34035,
  • RIKEN cDNA 2900016C05 gene,
  • expressed sequence AI425946,
  • RIKEN cDNA 6330408G06 gene,
  • MGI:2144809,
  • Gtl2,
  • DNA segment, Chr 12, Brigham & Women's Genetics 1266 expressed,
  • maternally expressed 3,
  • 3110050O07Rik,
  • Meg3,
  • D12Bwg1266e,
  • MGI:2145137,
  • gene trap locus 2,
  • MGI:105096,
  • 6330408G06Rik,
  • MGI:1914508,
  • R74756,
  • MGI:1917961
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