Primary Identifier | MGI:3619386 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 723858 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in energy homeostasis. Acts upstream of or within several processes, including cellular response to glucose stimulus; cellular response to mechanical stimulus; and long-term synaptic potentiation. Is expressed in testis. Orthologous to human MIR379 (microRNA 379). PHENOTYPE: While males show normal incidence of streptozotocin-induced insulin-dependent diabetes, they are protected from key features of diabetic kidney disease, including renal dysfunction, glomerular expansion, renal fibrosis, and glomerular basement membrane thickening compared to diabetic wild-type mice. [provided by MGI curators] |