| Primary Identifier | MGI:1306782 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 107585 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables thyroxine 5'-deiodinase activity and thyroxine 5-deiodinase activity. Involved in thyroid hormone catabolic process. Acts upstream of or within regulation of growth and retinal cone cell apoptotic process. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including extraembryonic component; female reproductive system; nervous system; sensory organ; and tongue. Orthologous to human DIO3 (iodothyronine deiodinase 3). PHENOTYPE: Mice homozygous for a null allele show partial embryonic or perinatal mortality, growth retardation, reduced fertility, and severe anomalies in thyroid status and physiology, including reduced T3 clearance and neonatal thyrotoxicosis followed by central hypothyroidism that persists throughout life. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
