| Primary Identifier | MGI:1915270 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 68020 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including mitochondrial cytochrome c oxidase assembly; positive regulation of cytochrome-c oxidase activity; and protein stabilization. Acts upstream of or within intrinsic apoptotic signaling pathway. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 17. Orthologous to human COA8 (cytochrome c oxidase assembly factor 8). PHENOTYPE: Homozygous KO leads to defects in the mitochondrial respiratory chain, resulting in impaired endurance, coordination and locomotor activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
