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Protein Coding Gene : Lgals8 lectin, galactose binding, soluble 8
Primary Identifier  MGI:1928481 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  56048
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables carbohydrate binding activity. Acts upstream of or within T cell costimulation and plasma cell differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human LGALS8 (galectin 8).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced VEGF-C-induced lymphangiogenesis, and ameliorated corneal pathology and lymphangiogenesis in a model of herpes simplex virus keratitis. Mice homozygous for a gene trapped allele exhibit hyperactivity. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 1200015E08 gene,
  • AI326142,
  • Lgals8,
  • Lgals-8,
  • lectin, galactose binding, soluble 8,
  • expressed sequence AI326142,
  • 1200015E08Rik,
  • MGI:1918987,
  • D13Ertd524e,
  • MGI:2145217,
  • MGI:1261882,
  • DNA segment, Chr 13, ERATO Doi 524, expressed
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