Primary Identifier | MGI:1347479 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 14238 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity and DNA-binding transcription factor activity. Involved in embryonic camera-type eye morphogenesis. Acts upstream of or within several processes, including embryonic digestive tract development; establishment of planar polarity of embryonic epithelium; and negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; ear; embryo mesenchyme; genitourinary system; and limb digit. Orthologous to human FOXF2 (forkhead box F2). PHENOTYPE: Homozygous mutant mice do not live through the first day of life due to an inability to suckle, which is secondary to cleft palate and tongue abnormalities. Mice homozygous for an ENU mutation exhibit postnatal lethality without palate defect and abnormal anterior segment dysgenesis. [provided by MGI curators] |