Primary Identifier | MGI:2145316 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 105245 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in protein folding. Located in endoplasmic reticulum lumen. Is expressed in several structures, including brain; eye; immune system; intestine; and male reproductive gland or organ. Orthologous to human TXNDC5 (thioredoxin domain containing 5). PHENOTYPE: Mcie homozygous for a null allele exhibit protection from isoproterenol-induced cardiac fibrosis and myocardial dysfunction. [provided by MGI curators] |