| Primary Identifier | MGI:1913393 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 66143 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of cell population proliferation; positive regulation of DNA damage response, signal transduction by p53 class mediator; and positive regulation of apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1). PHENOTYPE: Mice homozygous for a gene trap allele display early embryonic lethality while heterozygous mice exhibit prenatal semi-lethality and a significantly increased incidence of spontaneous tumorigenesis after 15 months of age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
