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Protein Coding Gene : Iars1 isoleucyl-tRNA synthetase 1
Primary Identifier  MGI:2145219 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  105148
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables isoleucine-tRNA ligase activity. Involved in isoleucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1).
PHENOTYPE: Homozygosity for the p.V79L mutation leads to reduced body weight and fatty liver. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI327140,
  • RIKEN cDNA E430001P04 gene,
  • 2510016L12Rik,
  • AU044614,
  • Iars1,
  • RIKEN cDNA 2510016L12 gene,
  • AI327140,
  • isoleucyl-tRNA synthetase 1,
  • Iars,
  • MGI:2145377,
  • expressed sequence AU044614,
  • E430001P04Rik,
  • MGI:7482294,
  • MGI:1917556,
  • isoleucine-tRNA synthetase
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1 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

3 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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