| Primary Identifier | MGI:1891012 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 58992 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables peptidase activity. Acts upstream of or within blood coagulation. Located in extracellular space. Is expressed in embryo; liver; and liver lobe. Used to study factor XII deficiency. Human ortholog(s) of this gene implicated in angioedema (multiple); cerebrovascular disease (multiple); factor XII deficiency; and myocardial infarction. Orthologous to human F12 (coagulation factor XII). PHENOTYPE: Mice homozygous for a knock-out allele are protected from ischemic brain injury in an experimental stroke model, without exhibiting an increase in infarct-associated hemorrhage. Another null mouse shows decreased plasma bradykinin levels and prolonged activated partial thromboplastin times. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
