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Protein Coding Gene : Erap1 endoplasmic reticulum aminopeptidase 1
Primary Identifier  MGI:1933403 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  80898
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables aminopeptidase activity. Acts upstream of or within positive regulation of angiogenesis and proteolysis. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1).
PHENOTYPE: Mice homozygous for a targeted mutation may exhibit extramedullary hematopoiesis of the spleen, thymus hyperplasia, or enlarged kidneys at older ages. [provided by MGI curators]
  • synonyms:
  • endoplasmic reticulum aminopeptidase 1,
  • ERAAP,
  • Arts1,
  • type 1 tumor necrosis factor receptor shedding aminopeptidase regulator,
  • Erap1,
  • PILSAP
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Features --> Cross References

Genome

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0 Canonical

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1 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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