| Primary Identifier | MGI:1098236 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 12380 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium-dependent cysteine-type endopeptidase inhibitor activity and protease binding activity. Acts upstream of or within negative regulation of peptidase activity. Located in membrane. Is expressed in several structures, including alimentary system; gonad; immune system; lung; and nervous system. Human ortholog(s) of this gene implicated in PLACK syndrome; Parkinson's disease; autoimmune disease (multiple); congenital myasthenic syndrome 1A; and vasculitis. Orthologous to human CAST (calpastatin). PHENOTYPE: Mice homozygous for a knockout allele exhibit augmented DNA fragmentation in CA1 pyramidal neurons following excitotoxic kainate treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
