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Protein Coding Gene : Glrx glutaredoxin
Primary Identifier  MGI:2135625 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  93692
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable glutathione disulfide oxidoreductase activity and sodium channel regulator activity. Predicted to be involved in positive regulation of membrane potential. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; extraembryonic component; and nervous system. Orthologous to human GLRX (glutaredoxin).
PHENOTYPE: Mice homozygous for a null allele do not exhibit any increased injury in response to oxidative insults to the heart or lungs but mouse embryonic fibroblast derived from these embryos are more sensative to diquat and paraqut and more resistant to apoptosis induced by TNF-alpha plus actinomyosin D. [provided by MGI curators]
  • synonyms:
  • MGI:2145532,
  • expressed sequence C86710,
  • glutaredoxin,
  • MGI:107593,
  • MGD-MRK-36165,
  • TTase,
  • Glrx,
  • C86710,
  • D13Wsu156e,
  • Grx1,
  • DNA segment, Chr 13, Wayne State University 156, expressed
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

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1 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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