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Protein Coding Gene : Vcan versican
Primary Identifier  MGI:102889 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  13003
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables protein phosphatase binding activity. Involved in ureteric bud development. Acts upstream of or within heart development. Located in extracellular matrix. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and jaw. Human ortholog(s) of this gene implicated in intracranial aneurysm. Orthologous to human VCAN (versican).
PHENOTYPE: Homozygotes for an insertional mutation exhibit anterior-posterior segmental defects of the heart, lack endocardial cushions of the conus and atrioventricular region, and die and around embryonic day 10.5. Homozygosity for a cleavage-resistant mutant leads to reduced embryonic survival, syndactyly and enhanced wound healing. [provided by MGI curators]
  • synonyms:
  • heart defect,
  • DPEAAE,
  • Vcan,
  • Cspg2,
  • hdf,
  • MGI:1918683,
  • 5430420N07Rik,
  • versican,
  • RIKEN cDNA 5430420N07 gene,
  • MGD-MRK-23722,
  • MGI:894331,
  • PG-M,
  • chondroitin sulfate proteoglycan 2
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

15 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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