| Primary Identifier | MGI:1298220 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 17951 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ATP binding activity. Involved in positive regulation of interleukin-1 beta production; pyroptotic inflammatory response; and response to bacterium. Acts upstream of or within symbiont entry into host cell. Part of IPAF inflammasome complex. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and retina. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). PHENOTYPE: This locus controls resistance to Legionella pneumophila, the organism responsible for Legionnaire's disease. Cultured peritoneal macrophages from A/J mice are susceptible, supporting bacterial proliferation; other strains, e.g., C57BL/6 are resistant. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
