| Primary Identifier | MGI:102956 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 12572 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables protein kinase activity. Predicted to be involved in several processes, including protein stabilization; regulation of G1/S transition of mitotic cell cycle; and transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; and transcription by RNA polymerase II. Located in nucleus. Is expressed in future hindbrain and telencephalon. Orthologous to human CDK7 (cyclin dependent kinase 7). PHENOTYPE: Mice homozygous for null allele exhibit abnormal trophoblast layer morphology, abnormal inner cell mass apoptosis, and complete embryonic lethality during peri-implantation stages. Homoyzgous null MEFs display absent fibroblast proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
