| Primary Identifier | MGI:1919066 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 71816 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including norepinephrine metabolic process; positive regulation of protein metabolic process; and serotonin metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal medulla; central nervous system; genitourinary system; lens; and thymus. Orthologous to human RNF180 (ring finger protein 180). PHENOTYPE: Knock-out mice show impaired stress responses, enhanced anxiety, and affiliative behavior. Norepinephrine and serotonin levels are decreased in the locus ceruleus, prefrontal cortex, and amygdala and MAO-A enzyme activity is enhanced in the locus ceruleus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
