Primary Identifier | MGI:2442377 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 76582 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables nuclear import signal receptor activity. Acts upstream of or within ribosomal protein import into nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including early conceptus; germ cell of gonad; and islets of Langerhans. Orthologous to human IPO11 (importin 11). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis. [provided by MGI curators] |