| Primary Identifier | MGI:1314633 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 13421 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables endonuclease activity. Involved in several processes, including DNA catabolic process; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Acts upstream of or within apoptotic DNA fragmentation and programmed cell death involved in cell development. Located in nucleus. Orthologous to human DNASE1L3 (deoxyribonuclease 1L3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired necrosis-associated internucleosomal DNA fragmentation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
