| Primary Identifier | MGI:2145814 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 105675 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cyclosporin A binding activity; peptide binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; regulation of proton transport; and response to ischemia. Acts upstream of or within several processes, including apoptotic mitochondrial changes; mitochondrial depolarization; and skeletal muscle fiber differentiation. Located in mitochondrion. Part of mitochondrial permeability transition pore complex. Is expressed in lower jaw tooth and tooth. Orthologous to human PPIF (peptidylprolyl isomerase F). PHENOTYPE: Homozygous inactivation of this gene results in abnormal mitochondrial physiology and a significantly decreased infarction size following ischemia/reperfusion-induced cardiac or brain injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
