Primary Identifier | MGI:1931466 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 80795 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of defense response to virus by host; and protein palmitoylation. Acts upstream of or within several processes, including macrophage derived foam cell differentiation; positive regulation of leukocyte migration; and respiratory burst after phagocytosis. Located in endoplasmic reticulum membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SELENOK (selenoprotein K). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired T cell, neutrophil, and macrophage calcium flux and increased susceptibility to viral infection. [provided by MGI curators] |