Primary Identifier | MGI:1860775 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 56249 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of Ino80 complex. Is expressed in several structures, including early conceptus; liver; metanephros; and oocyte. Orthologous to human ACTR8 (actin related protein 8). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis. [provided by MGI curators] |