Primary Identifier | MGI:1201374 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 11752 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including actin filament binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in endosomal transport; endosome organization; and negative regulation of hydrolase activity. Predicted to be located in cytosol; late endosome membrane; and plasma membrane. Predicted to be active in cytoplasm; sarcolemma; and vesicle membrane. Is expressed in several structures, including genitourinary system; gut; respiratory system; sensory organ; and skin. Orthologous to human ANXA8 (annexin A8) and ANXA8L1 (annexin A8 like 1). PHENOTYPE: Mice homozygous for a floxed allele activated in all cells exhibit impaired leukocyte rolling flux and adhesion. [provided by MGI curators] |