| Primary Identifier | MGI:95812 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 14803 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including regulation of postsynapse organization; social behavior; and synaptic signaling via neuropeptide. Part of trans-synaptic protein complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including brain; genitourinary system; gut; liver and biliary system; and spinal cord. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1). PHENOTYPE: Homozygotes for a targeted null mutation display a significant high-frequency hearing loss, associated with reductions of both cochlear outer hair cell function and endolymphatic potential, as well as increased vulnerability to acoustic injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
