| Primary Identifier | MGI:88563 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 13035 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including caspase binding activity; heparin binding activity; and serine-type endopeptidase activity. Acts upstream of or within defense response to fungus; positive regulation of immune response; and response to bacterium. Predicted to be located in several cellular components, including cytoplasmic stress granule; lysosome; and secretory granule. Predicted to be active in extracellular space. Is expressed in liver. Used to study acute myeloid leukemia. Orthologous to human CTSG (cathepsin G). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased susceptibility to bacterial infection induced mortality but increased susceptibility to mortality induced by fungal infection. Mice either homozygous or heterozygous for a knock-in allele develop an abrupt onset, rapidly fatal acute leukemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
