| Primary Identifier | MGI:1923257 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 76007 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable ubiquitin conjugating enzyme binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in PML body. Is expressed in several structures, including 2-cell stage conceptus; 4-8 cell stage conceptus; blastocyst-stage conceptus; genitourinary system; and main olfactory bulb. Orthologous to human ZMYM2 (zinc finger MYM-type containing 2). PHENOTYPE: Homozygous inactivation of this gene results in decreased embryo size, embryonic growth retardation, and complete lethality during organogenesis. Mice homozygous for a knock-out allele exhibit embryo turning and branchial arch/pouch defects, an abnormally shaped head, heart and tail, incomplete cranial neural tube closure, abnormal yolk sac vasculature, and an expanded spongiotrophoblast layer. Mice heterozygous for a transposon induced mutation show genitourinary defects, increased anxiety and aggressive-like behaviors, and glucose metabolism disorders. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
