| Primary Identifier | MGI:98715 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 21821 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables kinesin binding activity. Involved in regulation of autophagosome assembly and regulation of cilium assembly. Acts upstream of or within several processes, including circulatory system development; nervous system development; and spermatid development. Located in several cellular components, including ciliary base; cytoskeleton; and non-motile cilium. Part of intraciliary transport particle B. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and limb. Used to study autosomal recessive polycystic kidney disease; mitral valve disease; and scimitar syndrome. Orthologous to human IFT88 (intraflagellar transport 88). PHENOTYPE: Mice homozygous for a null allele display early to mid-gestation lethality, random patterning of the left-right body axis, neural tube defects, pericardial sac expansion, enlarged limb buds, polydactyly, and absent embryonic node cilia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
