Primary Identifier | MGI:1914403 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 67153 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including in utero embryonic development; positive regulation of fibroblast proliferation; and regulation of cell cycle phase transition. Part of ribonuclease H2 complex. Is expressed in several structures, including brain; gut; hemolymphoid system; skin; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality associated with reduced cell proliferation and embryonic growth retardation. [provided by MGI curators] |