| Primary Identifier | MGI:2137913 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 94352 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable metal ion binding activity; oligosaccharide binding activity; and protein-lysine 6-oxidase activity. Involved in negative regulation of stem cell population maintenance; positive regulation of chondrocyte differentiation; and response to hypoxia. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in brain; chondrocranium; renal cortical interstitium; and visceral epithelium of mature renal corpuscle. Orthologous to human LOXL2 (lysyl oxidase like 2). PHENOTYPE: Homozygous null mice show partial perinatal lethality associated with cardiac defects and distended liver blood vessels. Overexpressing mice display male sterility, testis degeneration, epididymal dysfunction, and increased tumor burden and malignant progression after DMBA-TPA treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
