| Primary Identifier | MGI:107162 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 19057 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-dependent protein serine/threonine phosphatase activity. Acts upstream of or within penetration of zona pellucida. Located in mitochondrion and sperm mitochondrial sheath. Part of calcineurin complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in gastrocnemius muscle; ovary; renal vasculature; and upper jaw molar. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility due to reduced hyperactivated sperm motility and midpiece rigidity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
