| Primary Identifier | MGI:2384851 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 213053 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables monoatomic anion:monoatomic cation symporter activity and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to glucose stimulus; intracellular zinc ion homeostasis; and transition metal ion transport. Acts upstream of or within iron ion transport and zinc ion transport. Located in basolateral plasma membrane. Is expressed in several structures, including autopod; dentate gyrus subgranular zone; ear; liver; and skeleton. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14). PHENOTYPE: Homozygotes for a null allele show dwarfism, scoliosis, osteopenia, short long bones, altered gluconeogenesis and chondrocyte differentiation, low plasma IGF-I and liver zinc levels. Homozygotes for another null allele show reduced liver zinc levels and hepatocyte proliferation after hepatectomy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
