| Primary Identifier | MGI:2443111 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 239273 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Predicted to be involved in several processes, including cAMP transport; carboxylic acid transport; and urate transport. Predicted to act upstream of or within several processes, including cilium assembly; fatty acid derivative transport; and prostaglandin secretion. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). PHENOTYPE: Homozygous null mice are viable and fertile. Homozygotes for one null allele display impaired organic anion transport in the blood-brain and blood-cerebrospinal fluid barriers and kidney. Homozygotes for a second null allele display hypoalgesia and abnormal PGE2 physiology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
