Primary Identifier | MGI:2685145 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 239283 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable AMP binding activity; G protein-coupled adenosine receptor activity; and purine nucleoside binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in epididymis; metanephros; neural retina; and retina. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human OXGR1 (oxoglutarate receptor 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced leukotriene E4 ligand (LTE4)-induced ear edema at low and intermediate doses and abnormal acid-base balance. [provided by MGI curators] |