| Primary Identifier | MGI:1913520 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 66270 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables endoplasmic reticulum-autophagosome adaptor activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including collagen catabolic process; macroautophagy; and white fat cell differentiation. Located in cis-Golgi network and endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; ganglia; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2B. Orthologous to human RETREG1 (reticulophagy regulator 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased thermal nociceptive threshold and sensory neuron degeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
