| Primary Identifier | MGI:1289282 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 52521 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable preribosome binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Predicted to be located in Golgi apparatus; cytosol; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including central nervous system; early conceptus; and neural retina. Orthologous to human ZNF622 (zinc finger protein 622). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
