| Primary Identifier | MGI:1918040 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 70790 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Acts upstream of or within negative regulation of interleukin-17 production and regulation of protein stability. Predicted to be located in several cellular components, including chromatin; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cranial ganglion; nervous system; sensory organ; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). PHENOTYPE: Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
