Primary Identifier | MGI:99257 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 16341 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex. Is active in postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; mammary gland; notochord; and spleen. Orthologous to human EIF3E (eukaryotic translation initiation factor 3 subunit E). PHENOTYPE: Mice homozygous for a null allele exhibit prenatal lethality with reduced embryo size, cell size and fetal membranes. Mice heterozygous for a null allele exhibit reduced size, weight, MEF cell proliferation and MEF translation. [provided by MGI curators] |