| Primary Identifier | MGI:95481 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 14083 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including positive regulation of ubiquitin-dependent protein catabolic process; protein phosphorylation; and regulation of modification of postsynaptic actin cytoskeleton. Acts upstream of or within several processes, including blood vessel morphogenesis; generation of neurons; and negative regulation of nervous system development. Located in several cellular components, including apical plasma membrane; focal adhesion; and lamellipodium. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and vault of skull. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). PHENOTYPE: Mice homozygous for a null allele die before or during organogenesis with growth retardation, abnormal embryonic and extra embryonic tissue development, and abnormal vascular development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
