| Primary Identifier | MGI:1913906 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 66656 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; guanyl-nucleotide exchange factor activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to heat; cellular response to ionizing radiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). PHENOTYPE: Mice homozygous for a selective deletion of the long isoform exhibit severe audiogenic seizures and show hypoactivity, decreased brain weight, hippocampus and midbrain atrophy, a thin cerebral cortex as well as increased protein synthesis and reticulum stress in response to aversive stimuli. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
