| Primary Identifier | MGI:1333825 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 13350 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; and retinol O-fatty-acyltransferase activity. Involved in several processes, including acylglycerol metabolic process; fatty acid homeostasis; and long-chain fatty-acyl-CoA metabolic process. Located in intracellular membrane-bounded organelle and membrane. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; genitourinary system; liver; skin; and yolk sac. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). PHENOTYPE: Homozygous inactivation of this gene leads to decreased percent body fat, resistance to diet-induced obesity, altered energy, glucose and triglyceride metabolism, alopecia, hair cycle and skin defects, and a lactation failure associated with impaired mammary gland growth during pregnancy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
