| Primary Identifier | MGI:96922 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 17189 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including nitrite reductase activity; oxygen binding activity; and oxygen carrier activity. Acts upstream of or within several processes, including brown fat cell differentiation; enucleate erythrocyte differentiation; and response to hypoxia. Predicted to be located in sarcoplasm. Is expressed in brown fat; heart; skeletal muscle; and somite. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human MB (myoglobin). PHENOTYPE: Homozygotes for a null allele show increased cardiac capillary density, coronary flow, hemoglobin and hematocrit levels. Many mice homozygous for another null allele die of heart failure at midgestation; survivors show hypervascularity, altered NO metabolism, and hypoxia-induced cardiac dysfunction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
