| Primary Identifier | MGI:108399 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 21411 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Phelan-McDermid syndrome and autism spectrum disorder. Orthologous to human TCF20 (transcription factor 20). PHENOTYPE: Mice homozygous for a null allele exhibit 80% lethality by P14, growth retardation, impaired neurogenesis, and decreased vocalization. Heterozygous mice show repetitive behaviors, social interaction defects, impaired working memory, and increased anxiety and vocalization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
