Primary Identifier | MGI:1922709 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 75459 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in reciprocal meiotic recombination; spermatogenesis; and synaptonemal complex assembly. Acts upstream of or within positive regulation of apoptotic process; positive regulation of developmental process; and positive regulation of reproductive process. Located in central element. Is expressed in embryo; ovary; and testis. Orthologous to human SYCE3 (synaptonemal complex central element protein 3). PHENOTYPE: Mice homozygous for a null mutation display male and female infertility, impaired double strand break repair and absence of synapsis during meiosis, absence of mature gametes, and small testes and ovaries. [provided by MGI curators] |