Primary Identifier | MGI:1926555 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 60597 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables kinesin binding activity. Involved in several processes, including behavioral fear response; excitatory postsynaptic potential; and regulation of neurotransmitter receptor activity. Acts upstream of or within JNK cascade. Located in cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). PHENOTYPE: Mice homozygous for a null allele are smaller in size and exhibit male infertility. Mice homozygous for a different knock-out allele exhibit behavioral and cerebellar transmission deficits. [provided by MGI curators] |