| Primary Identifier | MGI:2146001 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 105833 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be located in ciliary basal body and motile cilium. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in 4th ventricle lateral recess; diencephalon roof plate; lateral ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 27. Orthologous to human CCDC65 (coiled-coil domain containing 65). PHENOTYPE: Mice homozygous for a knock-out allele show decreased body size, increased head size, enlarged lateral ventricles, and complete postnatal lethality, possibly due to hydrocephalus. Heterozygotes exhibit an increased number and average size of urethane-induced lung tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
